ClinPGx (Clinical Pharmacogenomics Resource) integrates the PharmGKB, CPIC and PharmCAT into a single resource. There is confusion in the community at times as to which project (e.g., PharmGKB or CPIC) does what, including specific functionality (i.e., CPIC writes genotype-based prescribing guidelines, PharmGKB implements different ways to access those guidelines including specific diplotype recommendations and compares those recommendations from different resources including CPIC, other guideline groups, FDA PGx and biomarker tables). The multiple websites require significant effort to ensure that the databases/KBs stay in sync not only across these groups, but with outside resources. PharmGKB coordinates this synchronization as well as data deposition from these resources to ClinVar. In addition, multiple resources require more effort by having multiple Scientific Advisory Boards, Steering Committees and work by volunteers, applicant institutions, and the NIH to elucidate the specific job responsibilities (i.e., a curator on PharmGKB vs. PharmCAT vs. CPIC vs. PharmVar). Lastly, as mentioned above, this has created a siloing effect of PGx that cannot and should not be sustained.

Thus, we are excited that in the coming 18 months, we hope to formally launch ClinPGx with all resources below integrated. During this transitionary time, we will begin to introduce ClinPGx wherever appropriate, but will NOT be losing the branding of CPIC and the PharmGKB. For example, the CPIC guidelines will remain the CPIC guidelines and much of the organizational structure for CPIC will remain the same. The big difference will be that you would obtain the CPIC guidelines from the ClinPGx website and the CPIC website will be deprecated.

Parts of ClinPGx

Catalog human genetic variation that impacts drug response phenotype

Create and disseminate gene/drug clinical practice guidelines

Generate interpretation report with prescribing guidance from genomic data

Assign allele nomenclature for pharmacogene haplotypes